Global improvement in cancer survival but international differences are still very wide

While brain tumor survival in children has improved in many countries, 5-year survival is twice as high in Denmark and Sweden (around 80%) as in Mexico and Brazil (less than 40%) for children diagnosed as recently as 2014. This is likely to reflect the availability and quality of diagnostic and treatment services.

Cancer survival is generally increasing, even for some of the more deadly cancers such as liver and lung, according to the largest and most up-to-date study of population-based survival trends (2000–2014), covering countries that are home to more than two-thirds of the world’s population. But survival trends vary widely, and there are wide and persistent disparities between countries, particularly for some childhood cancers.

For example, while brain tumor survival in children has improved in many countries, 5-year survival is twice as high in Denmark and Sweden (around 80%) as in Mexico and Brazil (less than 40%) for children diagnosed as recently as 2014. This is likely to reflect the availability and quality of diagnostic and treatment services.

The CONCORD-3 study, published in The Lancet, analyzed individual patient records from 322 cancer registries in 71 countries and territories to compare 5-year survival from diagnosis for more than 37.5 million adults (aged 15–99 years) and children (0–14 years) with one of 18 common cancers.


These cancers represent three-quarters of all cancers diagnosed worldwide every year between 2000 and 2014. For the 10 cancers already included in the CONCORD-2 study, the researchers were able to examine trends over the 20-year period 1995¬2014.


The Organisation for Economic Co-operation and Development (OECD) is now using the CONCORD survival estimates to compare health system performance in 48 countries worldwide.

However, in some parts of the world, estimation of survival is limited both by incomplete data and by legal or administrative obstacles to updating the cancer records with each patient’s date of death. For example, in Africa as many as 40% of records contained incomplete follow-up data, so survival trends could not be systematically assessed.

Lead author Dr Claudia Allemani from the Cancer Survival Group at the London School of Hygiene & Tropical Medicine explains, “Continuous monitoring of global trends in cancer survival is crucial to assess the overall effectiveness of health systems worldwide and to help policy-makers plan better strategies for cancer control. But, inadequate or unreliable data prevent governments from understanding the true nature and magnitude of the public health problems created by the growing cancer burden. This leaves governments poorly equipped to develop national cancer plans that will translate into real improvements in survival for patients.”

She adds, “Governments must recognize cancer registries as efficient public health instruments that produce a continuous stream of valuable information on both the impact of cancer prevention strategies and the effectiveness of health systems and at very low cost. In Europe, the cost of registering one case is less than the cost of a chest x-ray, and without this kind of information, health ministries are flying blind on cancer control.”


After taking into account international differences in the age profile of cancer patients and the risk of death from other causes, survival for most cancers has been consistently high over the last 15 years in a handful of countries—the USA, Canada, Australia, New Zealand, Finland, Norway, Iceland, and Sweden.

For example, for women diagnosed with breast cancer in the USA and Australia between 2010 and 2014, 5-year survival is 90%, compared to 66% for women diagnosed in India. Within Europe, 5-year breast cancer survival increased to 85% or more in 16 countries including the UK, compared with a low of 71% in Eastern Europe (Russia).

In the UK, overall cancer survival is improving, with several cancers showing substantial increases in 5-year survival between 2000 and 2014, including breast (80% to 86%), prostate (82% to 89%), rectum (55% to 63%) and colon (52% to 60%)—reflecting better cancer management.

However, adults with cancer continue to have lower 5-year survival than in other comparable countries for several common cancers, including myeloid malignancies (such as acute myeloid leukemia) and adult brain cancer.


Cancer survival has improved markedly in Denmark—so that, for the majority of cancers, the Danes have almost caught up with their Nordic counterparts—including prostate (64% in 2000–2004 to 86% in 2010–2014), lung (10% to 17%), oesophagus (8% to 14%), and rectum (53% to 65%). These rapid improvements over the past 15 years have been driven by better investment, accelerated patient pathways, with public monitoring of hospitals’ compliance with waiting times.


While liver and lung cancers remain rapidly lethal in high- and low-income countries alike, the past two decades have seen some important progress in 5-year survival in several nations. Liver cancer survival increased by more than 10% in Korea (11% to 27%), Sweden (5% to 17%), Portugal (8% to 19%), and Norway (6% to 19%). Similarly, lung cancer survival increased by 5–10% in 21 countries including the UK (7% to 13%) between 1995 and 2014, with most progress seen in China (8% to 20%), Japan (23% to 33%), and Korea (10% to 25%).

But not all major cancers have seen such improvements. Even in 2014, pancreatic cancer remained highly lethal in all countries, with 5-year survival typically less than 15%. “Greater international efforts are needed to understand the risk factors for this rapidly lethal cancer and to improve prevention, early diagnosis, and treatment”, says co-author Professor Michel Coleman from the London School of Hygiene & Tropical Medicine.


In parts of south-east Asia, 5-year survival from stomach cancer is more than twice as high as in most other countries, including the USA (33%) and the UK (21%). Between 2000–2004 and 2010–2014, 5-year survival increased from 49% to 69% in South Korea and from 51% to 60% in Japan.

These faster improvements in survival could be due to long-standing population-based endoscopic screening programmes, and the authors suggest that screening should be part of national control plans in countries like Russia, where gastrointestinal cancers are a huge public health problem.

In contrast, survival for melanoma of the skin in south-east Asia is generally lower than the rest of the world, possibly reflecting lower public awareness and a more prevalent lethal subtype (acral lentiginous melanoma).


This article has been posted by a News Hour Correspondent. For queries, please contact through [email protected]
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