Switching to Tresiba® from another basal insulin benefits people with diabetes regardless of whether or not their blood sugar levels are controlled. This is the conclusion of a post-hoc analysis of data from the EU-TREAT study collected in a real-world clinical setting among people with type 1 and type 2 diabetes.
In people with type 2 diabetes whose blood sugar levels were controlled (HbA1c <7.5%) with basal insulin prior to switching, Tresiba® significantly reduced the rate of hypoglycemia (low blood sugar levels) while maintaining blood sugar control. Results showed a 67% reduction in the rate of hypoglycemic events over six months after switching to Tresiba®, with an 11% lower dose of insulin.
In patients with uncontrolled type 1 or type 2 diabetes, switching to Tresiba® resulted in significantly improved glycaemic control without an increase in the risk of hypoglycemia or insulin dose. These results were sustained for up to 12 months after switching from another basal insulin, mainly insulin glargine U100 and insulin detemir.
In people with type 1 diabetes whose blood sugar levels were controlled, a 16% lower rate of hypoglycemia was observed over six months, and blood sugar control was maintained with a 13% lower dose of insulin.
“This new analysis shows that people with diabetes who have switched to Tresiba® in the real world benefit from this change, regardless of whether they did so to improve blood glucose control or reduce the risk of hypoglycemia,” said Mads Krogsgaard Thomsen, executive vice president and chief science officer at Novo Nordisk.
“This confirms that the benefits of Tresiba® seen in clinical trials are being reproduced in clinical practice.”
The main results of the EU-TREAT real-world evidence study reported earlier this year showed that people with type 1 and type 2 diabetes experienced a significant reduction in HbA1c six months after switching to Tresiba®. Rates of overall hypoglycemia were also significantly lower at six months after switching to Tresiba®. In people with type 1 diabetes, the rate of severe hypoglycemia was reduced by 85% and by 92% in people with type 2 diabetes. Similar reductions were seen at 12 months.
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