Link between benzodiazepines and mortality called into question

News Hour:

The association between benzodiazepine use and mortality — if one exists — may be smaller than previously reported, according to a retrospective cohort study in The BMJ.

Using a large U.S. healthcare database, researchers matched 1.7 million adults who initiated a benzodiazepine between 2004 and 2013 with 1.9 million who did not. Analyses were adjusted for over 200 potential confounders, including demographics and comorbidities.

Dr. Paul Mueller of NEJM Journal Watch General Medicine weighed in: “From the mortality standpoint, these results should be somewhat reassuring to patients and clinicians alike. However, clinicians should be mindful that benzodiazepine use is also associated with other adverse outcomes including falls and hip fracture, plus excess risk for overdose-related death in people who also take opioids.”

During the first 6 months of follow-up, all-cause mortality did not differ significantly between benzodiazepine initiators and non-initiators (9.3 and 9.4 events per 1000 person-years, respectively). Benzodiazepine initiation was associated with small but statistically significant increases in mortality among patients younger than 65 (hazard ratio, 1.09); when short-acting benzodiazepines were used; and when follow-up was extended to 12 months.

Avatar

This article has been posted by a News Hour Correspondent. For queries, please contact through [email protected]
No Comments

Join Epidemiology Congress 2019

Translate this News

Join the Facebook Group

Click here to join the Facebook group of News Hour

Popular Posts

Sacred Games exposes Rajshri Deshpande nude [video]
Banglalink and Facebook jointly launched the campaign "Learn More, be More"
SRK as Satyajit Ray! Here is the truth behind the poster
Anurag Kashyap shoots Kubra Saith 7 times nude and made her cry for frontal nudity scene [Video]
Huawei introduces EMI facilities for smartphone purchase in Bangladesh
World Heart Day rally organized in Guwahati

Advertisement

News of the Month

Scroll Up
%d bloggers like this: